Publications by authors named "K Lossl"
Study Question: Are there differences in psychosocial and physical wellbeing among women and male partners undergoing modified natural cycle (mNC) frozen embryo transfer (FET) in immediate compared to postponed cycles after ovarian stimulation (OS) and oocyte pick-up (OPU)?
Summary Answer: Significantly more women in the immediate group reported physical symptoms than women in the postponed group whilst fewer were emotionally affected by waiting time, although the latter difference lost statistical significance after adjustment for multiple testing.
What Is Known Already: Infertility and fertility treatment are known to cause psychosocial distress in women and couples longing for a child. The treatment may be long-term and delayed for various reasons, such as the elective postponement of FET after a fresh transfer without pregnancy or an elective freeze-all cycle, possibly further increasing the level of distress.
Purpose: Breast cancer (BC) is the most prevalent cancer in women and radiotherapy (RT) is an integral part of its treatment. High-level evidence guides clinical decisions, but given the abundance of guidelines, a need to navigate within the evidence has been identified by the board of the Scientific Association of Swiss Radiation Oncology (SASRO). A pilot project was initiated aiming to create an overview of recent clinically relevant evidence for BC RT, to make it easily available to (radiation) oncologists and radiation oncologists in training.
View Article and Find Full Text PDFArticle Synopsis
- - Autologous postmastectomy breast reconstruction shows better long-term clinical outcomes and patient satisfaction compared to implant-based methods, but adjuvant radiotherapy has often been seen as a barrier to immediate reconstruction.
- - Recent advancements in postmastectomy radiotherapy (PMRT) have reduced complications, yet plastic surgeons remain cautious about offering immediate flap-based reconstruction to patients requiring radiotherapy.
- - At a recent workshop, experts concluded that PMRT should not be viewed as a deterrent to immediate autologous reconstruction, emphasizing goals like symmetry, softness, and skin preservation in the reconstruction process.
Research Question: How is the production of progesterone (P) and 17-hydroxy-P (17-OH-P) regulated between theca cells and granulosa cells during the follicular phase, during ovulation and after transformation into a corpus luteum?
Design: Three cohorts were examined: (i) 31 women undergoing natural and stimulated cycles, with serum hormone measurements taken every 3 days; (ii) 50 women undergoing ovarian stimulation, with hormone concentrations in serum and follicular fluid assessed at five time points during final follicle maturation; and (iii) 12 women undergoing fertility preservation, with hormone concentrations evaluated via the follicular fluid of small antral follicles.
Results: In the early follicular phase, theca cells primarily synthesized 17-OH-P while granulosa cells produced limited P, maintaining the P:17-OH-P ratio <1. As follicles reached follicle selection at a diameter of approximately 10 mm, P synthesis in granulosa cells was up-regulated, but P was mainly accumulated in follicular fluid.