Publications by authors named "K Lindenau"
Starting from the alkyne complex CpZr(py)(η-MeSiCSiMe) (Cp = η-cyclopentadienyl, py = pyridine), the synthesis and complete characterisation of a zirconocene(IV) triazenido hydride complex and its use in the activation of small molecules is reported. The reaction with CO led to the formation of a zirconocene(IV) triazenido-formate complex, which was further investigated for its stability towards different bases with respect to the formation of formic acid. The experimentally observed reaction pathway was investigated computationally using DFT methods, revealing the favourable role of pyridine coordination in the hydrogen transfer from the triazene to the alkyne unit of the zirconocene reagent.
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- Chaperone-mediated autophagy (CMA) is important for cellular health, but its activity decreases with age, particularly in the immune system due to lower levels of LAMP2A.
- * Researchers found that increasing LAMP2A in T cells can counteract some age-related declines in their function and improve immune responses.
- * The study suggests that maintaining CMA activity might be a promising strategy to enhance T cell effectiveness in older individuals, potentially using small molecule activators.
Chaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome homeostasis, and proteome changes required for the adaptation to stress. Loss of proteostasis is one of the hallmarks of aging. CMA decreases with age in multiple rodent tissues and human cell types.
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- CMA and endosomal microautophagy (eMI) are processes for selectively degrading specific cytosolic proteins in lysosomes and late endosomes, recognizing a key five-amino-acid motif with the help of the Hsc70 chaperone.
- This study reveals a compensatory relationship between CMA and eMI, highlighting the role of the chaperone Bag6 in managing the entry of eMI substrates into late endosomes.
- Starvation alters the behavior of Bag6 at late endosome membranes, leading to a decline in eMI activity, and the findings suggest a coordinated interaction between CMA and eMI, and a shared subproteome that both pathways target for degradation.
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory proteins per se controls adipogenesis remains largely understudied.
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