Relationships between ambulatory blood pressure, forearm vascular resistance, and left ventricular mass in hypertensive and normotensive subjects.

Ambulant 24 h blood pressure was recorded in 97 untreated hypertensive subjects (50 with, 47 without echocardiographic signs of left ventricular hypertrophy) and 45 matched normotensive subjects. Forearm vascular resistance was calculated from mean blood pressure and blood flow, which was measured by venous plethysmography during reactive hyperemia. Blood pressure variability was calculated by standard deviations of pressure values.

Relation of regression of left ventricular hypertrophy to changes in ambulatory blood pressure after long-term therapy with perindopril versus nifedipine.

Casual as well as ambulatory 24-hour blood pressure (BP) and echocardiographic parameters were studied in 40 patients with untreated or insufficiently treated mild to moderate essential hypertension. Left ventricular (LV) hypertrophy was assessed before and after 24 weeks of therapy with either the converting enzyme inhibitor perindopril or the calcium antagonist nifedipine. The design was a double-blind parallel study with a placebo run-in period.

[Value of 24-hour blood pressure measurement in patients with arterial hypertension, left heart enlargement and increased cardiac risk].

Non-invasive 24-h blood pressure and a 24-h electrocardiogram were recorded in 45 normotensive and 97 matched, untreated, hypertensive subjects, with and without echocardiographic signs of left-ventricular hypertrophy and without signs of coronary artery disease. Forearm vascular resistance was calculated from mean blood pressure and postischemic blood flow, which was measured by venous plethysmography. Systolic ambulant 24-h blood pressure exhibited the closest correlation with left-ventricular mass index in hypertensives (r = 0.

[Detection of cardiac risk in hypertensive patients with left heart hypertrophy].

Arterial hypertension is a consistent and modifiable cause of cardiovascular disease. The risk is further increased by left ventricular hypertrophy as an independent contributor to these cardiovascular events. However, the incidence of coronary mortality and sudden death could not be reduced by antihypertensive drug therapy.

Blood pressure profile and cardiac risk in hypertensive patients with left ventricular hypertrophy.

A study of normotensive volunteers and patients with primary hypertension demonstrated the superiority of a single 24-h mean systolic and diastolic ambulatory blood pressure monitoring (SpaceLabs 90207 ABPM) over standardized sphygmomanometric casual readings. In contrast to the casual blood pressure measurement there was a significant correlation between both 24-h mean systolic and diastolic blood pressures and left ventricular hypertrophy as assessed by two-dimensional M-mode echocardiography. Although no significant differences between daytime and night-time blood pressure were demonstrated in normotensive or hypertensive subjects with or without target organ damage, larger prospective trials are required to confirm this finding.