Publications by authors named "K Liapis"
• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations.
View Article and Find Full Text PDFSingle-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine.
Athanasios Tasis Nikos E Papaioannou Maria Grigoriou Nikolaos Paschalidis Catherine Loukogiannaki Konstantinos Liapis
Cancer Res Commun
December 2024
Article Synopsis
- CD8+ T cells play a vital role in fighting cancer, but their functionality is compromised in higher-risk myelodysplastic neoplasms (HR-MDS) and acute myeloid leukemia (AML).
- An analysis of 104 pre-treatment bone marrow samples revealed that patients who did not respond to azacitidine therapy had higher levels of a specific CD8+ T cell subset (CD57+CXCR3+), which was linked to worse survival outcomes.
- The study also highlighted that successful treatment responses were associated with stronger IFN signaling, while non-responders showed increased TGF-β signaling, suggesting that combining TGF-β inhibitors with azacitidine could improve treatment in these cancer types.
There is remarkable morphologic and genetic heterogeneity in acute myeloid leukemia (AML). In a small percentage of cases of AML, increased eosinophils and/or basophils are present in the bone marrow and sometimes in the peripheral blood. This is often a puzzling diagnostic situation but also an important finding that requires special investigation.
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