Publications by authors named "K Lechner"
Cardiovascular risk factors (high blood pressure, smoking, overweight, type 2 diabetes, dyslipidemia, physical inactivity) substantially rise with increasing age, particularly after middle age, whereby women are affected to a much greater extent. In the population of Saxony-Anhalt the prevalence of cardiovascular risk factors is clearly increased and the population structure in Saxony-Anhalt is particularly characterized by a high average age as well as high morbidity and mortality rates due to cardiovascular diseases. Saxony-Anhalt therefore provides a model character for the demographic development in Europe.
View Article and Find Full Text PDFBackground: Metabolic syndrome (MetS) is defined by the presence of central obesity plus ≥two metabolic/cardiovascular risk factors (RF), with inflammation being a major disease-driving mechanism. Structured endurance exercise training (ET) may positively affect these traits, as well as cardiorespiratory fitness (V̇Opeak).
Aims: We explore individual ET-mediated improvements of MetS-associated RF in relation to improvements in V̇Opeak and inflammatory profile.
Article Synopsis
- T-cell responses require two signals for effective activation: engagement of T-cell receptors (signal 1) and additional costimulatory signals (signal 2), which T-cell bispecific antibodies (TCBs) can provide by targeting specific antigens and CD3ε.
- The study introduces CD19-CD28, a bispecific CD19-targeted CD28 agonist, designed to enhance the effectiveness of glofitamab, a TCB targeting malignant B cells, by delivering the crucial costimulatory signal 2 needed for stronger T-cell responses.
- Initial results show that combining glofitamab with CD19-CD28 and the 4-1BB agonist significantly improves long
Article Synopsis
- The study focuses on understanding severe COVID-19 disease progression by analyzing the blood plasma of patients to identify specific serologic markers that could predict worsening symptoms like inflammation and blood clotting.
- Through extensive testing on seven critically ill patients, researchers used a statistical model to identify proteins that signal imminent increases in inflammatory responses and coagulopathy around 24-48 hours before they occur.
- The findings highlight the potential of certain proteins, which are involved in biological processes like inflammation and coagulation, to serve as predictive biomarkers for severe COVID-19, but further validation is needed to confirm their effectiveness.
De novo lipogenesis (DNL)-related monounsaturated fatty acids (MUFAs) in the blood are associated with incident heart failure (HF). This observation's biological plausibility may be due to the potential of these MUFAs to induce proinflammatory pathways, endoplasmic reticulum stress, and insulin resistance, which are pathophysiologically relevant in HF. The associations of circulating MUFAs with cardiometabolic phenotypes in patients with heart failure with a preserved ejection fraction (HFpEF) are unknown.
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