Publications by authors named "K LeBlanc"
The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [n = 5] or sleeve gastrectomy [n = 7]) or LCD (n = 7) in this parallel-arm, prospective observational study.
View Article and Find Full Text PDFBackground: Patients undergoing bariatric surgery may be at increased risk for postsurgical opioid dependence, highlighting a need for opioid-sparing anesthesia.
Objectives: Liposomal bupivacaine (LB), a prolonged release formulation of bupivacaine, may improve postoperative pain management and reduce postsurgical opioid use. This retrospective claims-database study investigated the effects of LB versus non-LB analgesia on opioid use and healthcare resource utilization (HCRU) in patients receiving laparoscopic sleeve gastrectomy (SG).
Background: Depression affects approximately 280 million individuals globally and it is a leading cause of disability. Despite effective medication options, 50% of patients prematurely discontinue antidepressants within 6 months. We sought to understand patients' perspectives regarding their needs and expectations related to antidepressants.
View Article and Find Full Text PDFArticle Synopsis
- - Abiraterone acetate, apalutamide, darolutamide, and enzalutamide are androgen receptor axis-targeted therapies (ARATs) used to treat prostate cancer, often alongside oral antithrombotic therapies, which may lead to significant drug-drug interactions.
- - A multidisciplinary expert panel used a modified electronic Delphi process to reach consensus on which ARAT/antithrombotic pairs should be monitored and how to manage these interactions, ultimately recommending avoiding 11 pairs and modifying therapy for 8 others.
- - This process underscores the need for more research into the clinical outcomes of ARAT and antithrombotic interactions while providing clinicians with actionable guidance for safer therapeutic choices. *
Ventral Hernia Repair With a Hybrid Absorbable-permanent Preperitoneal Mesh.
Surg Laparosc Endosc Percutan Tech
December 2024
Article Synopsis
- - The study focused on evaluating the safety and effectiveness of the GORE SYNECOR Preperitoneal Biomaterial (PRE device) for ventral hernia repairs, involving a retrospective review of outcomes for 148 patients over more than a year post-surgery.
- - Results showed a low incidence of adverse events within 30 days (8.8% overall), with the main complications being surgical site infections (4.8%) and the need for reoperations (2.0%). Importantly, no hernia recurrences were reported during the study.
- - The findings suggest that the PRE device is both safe and effective for complex repairs, combining the benefits of absorbable and permanent mesh materials when placed in the retromuscular