Publications by authors named "K Lazarus"
Redefining Diagnostic Cut-Offs for the Indirect Water Deprivation Test.
Clin Endocrinol (Oxf)
February 2025
Objective: An incorrect diagnosis of arginine vasopressin deficiency and resistance (AVP-D and AVP-R) results in the potentially dangerous use of desmopressin in healthy individuals. The water deprivation test is a central diagnostic test in patients with polydipsia polyuria syndrome (PPS). This study aims to determine the effectiveness of the current interpretation of reference ranges.
View Article and Find Full Text PDFA lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence.
Am J Physiol Lung Cell Mol Physiol
October 2024
Basal cells are adult stem cells in the airway epithelium and regenerate differentiated cell populations, including the mucosecretory and ciliated cells that enact mucociliary clearance. Human basal cells can proliferate and produce differentiated epithelium in vitro. However, studies of airway epithelial differentiation mostly rely on immunohistochemical or immunofluorescence-based staining approaches, meaning that a dynamic approach is lacking, and quantitative data are limited.
View Article and Find Full Text PDFArticle Synopsis
- * The study used latent class analysis to identify three subgroups based on their reported levels of discrimination, microaggressions, and resilience, finding that overall experiences of discrimination and microaggressions decreased while resilience increased over time.
- * Results emphasize the need for clinical interventions and policies to improve resilience and tackle barriers related to racism, sexism, and HIV stigma for better health outcomes among Black women living with HIV.
Black women living with HIV (BWLWH) face barriers that impact health outcomes. However, positive psychosocial indicators may influence HIV care outcomes. Among this cross-sectional study of 119 BWLWH, a network analysis was utilized to examine relationships between positive psychosocial factors and HIV-related health outcomes.
View Article and Find Full Text PDFBackground: Adrenal insufficiency (AI) is a life-threatening condition which requires long term glucocorticoid replacement. The insulin tolerance test (ITT) is the current gold standard test for diagnosis of secondary AI, but the widely accepted cut-off value of a peak cortisol of less than 500 nmol/L assumes that anyone who does not reach this value has AI and thus requires full replacement. The cut-off used to diagnose AI is also founded on outdated assays.
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