Publications by authors named "K Lattes"
Advanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we applied plexDIA, a multiplexed, single-cell mass spectrometry method, to analyze the proteome of oocytes from both young women and women of advanced maternal age.
View Article and Find Full Text PDFAdvanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we applied plexDIA, a multiplexed data-independent acquisition, single-cell mass spectrometry method, to analyze the proteome of oocytes from both young women and women of advanced maternal age.
View Article and Find Full Text PDFStudy Question: Does a personalized embryo transfer (pET) guided by tests for endometrial receptivity (TER) increase the effectiveness of ART procedures?
Summary Answer: The use of TER-guided pET is not supported by current published evidence in women without repeated implantation failure (RIF), while in women with RIF more research is needed to assess a potential benefit.
What Is Known Already: Implantation rates are still far from ideal, especially in some patients that have RIF with good-quality embryos. As a potential solution, a wide range of diverse TER use different sets of genes to identify displacements of the window of implantation to adjust the individual length of progesterone exposure in a pET.
Article Synopsis
- The study aimed to compare different ovarian stimulation approaches: traditional methods starting in the early follicular phase versus newer methods like luteal phase stimulation, random-start, and DuoStim.
- A systematic review of various trials showed that "Luteal" stimulation did not lead to clinically significant differences in mature oocyte counts compared to conventional methods, but it may extend the length of controlled ovarian hyperstimulation (COH).
- For poor responders, DuoStim may result in more MII oocytes compared to conventional stimulation, suggesting non-conventional methods offer flexibility with similar outcomes, though further research is needed for more definitive conclusions.
A freeze-all strategy does not increase live birth rates in women of advanced reproductive age.
J Assist Reprod Genet
October 2020
Research Question: Does a freeze-all strategy improve live birth rates in women of different age groups?
Design: Retrospective cohort study of 1882 first embryo transfer cycles, performed between January 2013 and December 2015. Reproductive outcomes between fresh (FRESH) or frozen (FROZEN) embryo transfers were compared in patients stratified by age: < 35, between 35 and 38, or > 38 years. Student's t test for independent samples and χ analyses were used as needed.