Patient-Reported Outcomes for Low-Risk Ductal Carcinoma In Situ: A Secondary Analysis of the COMET Randomized Clinical Trial.

Importance: Active monitoring (AM) for low-risk ductal carcinoma in situ (DCIS) has been considered as a potential alternative to guideline-concordant care (GCC; inclusive of surgery with or without radiation). Reported data comparing patient-reported outcomes (PROs) between GCC and AM for DCIS are lacking.

Objective: To compare PROs at baseline and over time in patients with low-risk DCIS randomized to receive either AM or GCC.

Active Monitoring With or Without Endocrine Therapy for Low-Risk Ductal Carcinoma In Situ: The COMET Randomized Clinical Trial.

Importance: Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but the safety of this approach is unknown.

Objective: To compare rates of invasive cancer in patients with low-risk DCIS receiving active monitoring vs guideline-concordant care.

Design, Setting, And Participants: Prospective, randomized noninferiority trial enrolling 995 women aged 40 years or older with a new diagnosis of hormone receptor-positive grade 1 or grade 2 DCIS without invasive cancer at 100 US Alliance Cancer Cooperative Group clinical trial sites from 2017 to 2023.

Strain Partitioning in a Flattening Shear Zone: Re-Evaluation of a Cycladic Style Detachment.

The Almyropotamos tectonic window on southern Evia island in the NW Aegean Sea divides two high pressure-low temperature metamorphic units, representing distinct Hellenic thrust sheets. Ductile thinning along the major low-angle Evia Shear Zone has closely juxtaposed the lower (Basal Unit) marble-flysch sequence structurally below Styra marbles (Cycladic Blueschist Unit). The partially attenuated flysch comprises a matrix dominated by pelitic schist, with dispersed cm- to hm-scale blocks of marble, carbonate schist, quartzite, and metabasite.