Publications by authors named "K Landers"
Blood flow restriction exercise (BFRE) is a therapeutic approach traditionally used to facilitate muscular strength and hypertrophy. Emerging evidence has identified its benefits on other systems and metabolic processes. The emphasis of this study was to examine potential impact of BFRE on serum levels of tissue plasminogen activator (tPA).
View Article and Find Full Text PDFActivity-Based Photoacoustic Probes for Detection of Disease Biomarkers beyond Oncology.
ACS Bio Med Chem Au
June 2023
The earliest activity-based photoacoustic (PA) probes were developed as diagnostic agents for cancer. Since this seminal work over a decade ago that specifically targeted matrix metalloproteinase-2, PA instrumentation, dye platforms, and probe designs have advanced considerably, allowing for the detection of an impressive list of cancer types. However, beyond imaging for oncology purposes, the ability to selectively visualize a given disease biomarker, which can range from aberrant enzymatic activity to the overproduction of reactive small molecules, is also being exploited to study a myriad of noncancerous disease states.
View Article and Find Full Text PDFArticle Synopsis
- Rifampin-resistant tuberculosis is a major global health issue, with treatment initiation rates low and often poor outcomes; a 6-month BPaL regimen shows high efficacy but initial high doses of linezolid led to significant side effects.
- Data collected from patients treated with BPaL between October 2019 and April 2022 revealed that 97.1% completed treatment, with only a small percentage experiencing relapse or significant adverse effects, largely due to careful dose adjustments of linezolid.
- The study concludes that the BPaL regimen, especially with individualized linezolid dosing and monitoring, has significantly improved treatment for rifampin-resistant tuberculosis, allowing for shorter treatment durations compared to past guidelines.
The Arctic is rapidly warming posing a significant threat to underlying permafrost. Permafrost degradation has already resulted in extensive damage to the Arctic's built infrastructure, putting communities and industries at risk. Projected climate warming will further reduce the capacity of permafrost to support infrastructure, thereby requiring a rethinking of construction and development of permafrost regions in the future.
View Article and Find Full Text PDFBackground: Orbital defects have a profound impact on orbital function and symmetry of the face and are difficult to reconstruct given the complexity of this area. The paramedian forehead flap (PMFF) has not been well studied in reconstruction of orbital defects.
Methods: Retrospective review of patients who underwent reconstruction of periorbital defects with PMFF between 2016 and 2021.