Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma.

Multiple myeloma (MM) remains an incurable hematological malignancy that necessitates the identification of novel therapeutic strategies. Here, we report that intracellular levels of very long chain fatty acids (VLCFAs) control the cytotoxicity of MM chemotherapeutic agents. Inhibition of VLCFA biosynthesis reduced cell death in MM cells caused by the proteasome inhibitor, bortezomib.

Neglected Bilateral Shaft Femur Fracture - - A Case Report.

Introduction: Most patients with these injuries are taken to hospitals frequently for specialized orthopedic treatment. However, because quackery is a common practice in the many regions, it is common in underdeveloped nations, particularly in rural India, for these injuries to be initially overlooked. This study aimed to assess the efficacy of open intramedullary nailing in the treatment of patients with neglected bilateral fracture shaft femurs in terms of union achievement and functional outcomes.

Bilaterally Symmetrical Serratia Osteomyelitis of Distal Third Radius in an Adolescent Female with Sickle Cell Disease: A Rare Case Report.

Introduction: Osteomyelitis as a condition in adolescents is difficult to diagnose as it is. In patients with sickle cell disease, the diagnosis is even more difficult due to the occurrence of Vaso occlusive crisis which being the most common acute clinical manifestation of sickle cell disease in bone may mimic osteomyelitis. No single clinical presentation, laboratory result, or imaging finding can definitively distinguish these diagnoses.

Exploring the therapeutic mechanisms of millet in obesity through molecular docking, pharmacokinetics, and dynamic simulation.

Obesity, a prevalent global health concern, is characterized by excessive fat accumulation, which confers significant nutritional and health risks, including a shortened lifespan and diminished wellbeing. Central to the regulation of energy balance and food intake is the fat mass and obesity-associated (FTO) protein, which modulates the interplay between caloric consumption and energy expenditure. Given its pivotal role in obesity regulation, the identification of effective inhibitors targeting the FTO protein is imperative for developing therapeutic interventions.