Steroid anaesthesia: alphadione depresses multiunit activity in the mesencephalic reticular formation.

Cortical EEG and multiunit activity (MUA) of the mesencephalic reticular formation (MRF), area hypothalami anterior (AH) and the nucleus amygdalae basalis (AMY) were studied before and after different doses of alphadione (Althesin) and hexobarbitone (Evipan-Natrium) given to cats with chronically implanted electrodes. Non-anaesthetic doses of alphadione (0.15 ml/kg; 0.

Effects of drugs influencing the cAMP level on hippocampal seizure activity.

Changes of hippocampal EEF seizure activity elicited by electrical stimulation of the hippocampus or penicillin injection into the hippocampus were investigated under the effect of locally applied drugs influencing the cAMP level in the brain. It was observed that some drugs which elevate the cAMP level such as papaverine, histamine +K+ and dibutyryl cAMP elevated the electric seizure threshold while in penicillin-induced epilepsy they reduced the occurrence of ictal activity and the interictal spike frequency. These drugs when applied before penicillin prolonged the time necessary for development of the epileptic focus.

Early postnatal development of wakefulness-sleep cycle and neuronal responsiveness: a multiunit activity study on freely moving newborn rat.

The development of the wakefulness-sleep cycle and neuronal responsiveness was studied on freely moving 1-, 3-, 5- and 7-day-old rats. Semimicroelectrodes were implanted under ether anaesthesia for multiunit activity (MUA) recording from the mesencephalic reticular formation (MRF) and basal forebrain area (FB). Following recovery from surgery and between the recording sessions pups were put back to the nest to be fed by their mothers.