Causal Relationship Between Emotional Disorders and Thyroid Disorders: A Bidirectional Two-Sample Mendelian Randomization Study.

Introduction: The interplay between emotional disorders and thyroid disorders has been subject to numerous observational studies, which have consistently reported associations but have failed to establish clear causal links due to the multifactorial etiology and influences. We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to explore the genetic causal association between emotional disorders and thyroid disorders.

Methods: We employed several methods, including inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression.

Less Is More: Donor Engineering of a Stable Molecular Dye for Bioimaging in the NIR-IIb Window.

Fluorescence molecular imaging aims to enhance clarity in the region of interest, particularly in the near-infrared IIb window (NIR-IIb, 1500-1700 nm). To achieve this, we developed a novel small-molecule dye, named , based on classic cyanine dyes (heptamethine or pentamethine is essential for wavelengths beyond 1000 nm). By reducing excessive polymethine to a single methine and disrupting symmetry to form an asymmetric donor-π-acceptor (D-π-A) architecture, we enhanced the donor's electron-donating capability, yielding emission at 1088 nm.

Hybrid Soft Segments Boost the Development of Ultratough Thermoplastic Elastomers with Tunable Hardness.

The hardness of thermoplastic elastomers (TPEs) significantly influences their suitability for various applications, but traditionally, enhancing hardness reduces toughness. Herein a method is introduced that leverages hybrid soft segments to fine-tune the hardness of TPEs without compromising their exceptional toughness. Through the selective copolymerization of polytetramethylene ether glycols (PTMEGs) at various molecular weights, supramolecular poly(urethane-urea) TPEs are molecularly engineered to cover a wide spectrum of hardness while retaining good toughness.

[Genetic evolution analysis of enteric cytopathogenic human orphan virus type 30 in three cases of infants and young children in Hubei Province].

Three throat swab samples from infants and young children in Hubei Province were identified as positive for enteroviruses. All subjects were one month old, and the onset of symptoms occurred in June; these cases were sporadic and exhibited no clear epidemiological associations. The results of VP1 gene amplification analysis indicated that all three infant cases were attributed to Echovirus 30 (ECHO30).

Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type-I and AIE-Active Photosensitizers for Targeting Ferroptosis-Based Cancer Therapy.

Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation-induced emission (AIE) activity offer a promising solution to achieve non-invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type-I ROS generation are still scarce and the structure-property relationship is still unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed to endow the AIEgen strong type-I ROS producibility.