Multiomics analysis revealed the effects of polystyrene nanoplastics at different environmentally relevant concentrations on intestinal homeostasis.

Nanoplastics pollution is a global issue, with the digestive tract being one of the first affected organs, requiring further research on its impact on intestinal health. This study involved orally exposing mice to polystyrene nanoplastics (PS-NPs) at doses of 0.1, 0.

Biomimetic multilayered polymeric heart valve featuring ultra-thin thickness and exceptional durability.

The transcatheter aortic valve replacement technique has rapidly developed in clinical practice, with its indications expanding to low-risk populations and younger patients. The durability of valve materials has emerged as a critical requirement from a clinical perspective and a research focus in interventional valves. Polymeric heart valves exhibit a promising future because of their enhanced durability and reduced cost.

Tissue stiffness mapping by light sheet elastography.

Tissue stiffness plays a crucial role in regulating morphogenesis. The ability to measure and monitor the dynamic progression of tissue stiffness is important for generating and testing mechanistic hypotheses. Methods to measure tissue properties in vivo have been emerging but present challenges with spatial and temporal resolution especially in 3D, by their reliance on highly specialized equipment, and/or due to their invasive nature.

High-efficiency rectangular transverse air-gap metalens for visible light based on a dual-coupled PB phase.

Pancharatnam-Berry (PB) phase modulation leverages the precise linear correspondence between output phase and nanopillar rotation angle, enabling wide application in modulating focal spherical waves. However, the intrinsic material absorption of waveguide structure inevitably brings energy loss within the visible light spectral range, severely limiting focusing efficiency over broad bandwidths under general models of nanopillars. Here, we introduce a dual-coupled metalens composed of an air slot-etched rectangular TiO nanopillar, and the extremely narrow air gap along its long axis of nanopillar can be regarded as a high-aspect-ratio rectangular waveguide for strictly confining the incident light.

Dose-dependent developmental fluoride exposure leads to neurotoxicity and impairs excitatory synapse development.

Developmental fluoride exposure has been implicated in cognitive deficits and neurotoxicity, yet the mechanisms underlying these effects remain unclear. Here, we investigated the dose- and time-dependent impacts of sodium fluoride (NaF) on neuronal morphology, viability, oxidative stress, and synaptic function using both in vitro and in vivo mouse models. Cultured primary embryonic mouse cortical neurons were exposed to varying concentrations of NaF (0-200 μg/ml).