Publications by authors named "K L Wycoff"
Article Synopsis
- Lyme disease (LD), caused by the Lyme borreliae bacteria, is the most prevalent vector-borne illness in the northern hemisphere, with no effective prevention methods currently available.
- The study reveals that chimeric proteins specifically designed to interact with host complement inhibitors can effectively kill Lyme borreliae and reduce related joint inflammation in mice.
- Notably, the research shows that one protein variant (SCR(6-7)-Fc) targets specific Lyme borreliae strains, while another variant (SCR(19-20)-Fc) has a broader effect, killing various bacterial species and highlighting the potential of these constructs as preventive measures against LD.
Chagas disease, a chronic disabling disease caused by the protozoan , has no standardized treatment or preventative vaccine. The infective trypomastigote form of is highly resistant to killing by the complement immune system. Factor H (FH), a negative regulator of the alternative pathway (AP) of complement on cell surfaces and in blood, contains 20 short consensus repeat domains.
View Article and Find Full Text PDFObjective: To explore how patients, community-based perinatal support professionals, and health system clinicians and staff perceived facilitators and barriers to implementation of a randomized clinical trial (RCT) designed to optimize Black maternal heart health.
Methods: This article describes the formative work that we believed needed to occur before the start of the Change of H.E.
HP's Multi Jet Fusion is a powder bed fusion 3D printing technology that utilizes a carbon-based radiation absorber in combination with a near infrared (NIR) light source to facilitate the fusion of polymer powder in a layer-by-layer fashion to generate 3D parts. Most available carbon-based and NIR radiation absorbers have an intrinsic dark color, which as a result will only produce black/gray and dark colored parts. However, there are many applications that require variable color, including prosthetics, medical models, and indicators, among others.
View Article and Find Full Text PDFIntroduction: In urban areas, numerous barriers exist for children and families to access needed behavioral health care. Compounding the general deficit of behavioral health workers in the United States is lack of access to culturally responsive care. Additional challenges include inherent racism and oppression in our health and human service systems and siloed approaches to behavioral health care training and practice.
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