Publications by authors named "K L Stearns"
Article Synopsis
- High-grade serous ovarian cancer (HGSC) shows resistance to immunotherapy but some patients have partial or complete responses, indicating a potential molecular basis for immunity in specific subpopulations.
- An algorithm called CONSTRU was developed to analyze gene expression profiles in HGSC and identify genetic factors that influence the effectiveness of anti-tumor immunity, resulting in a stratification signature (STRATsig) that divides patients into groups based on their immune response.
- Results indicated that patient survival and immune function varied significantly among these groups, with one group (S-T1) exhibiting strong immune suppression and dysfunction, while another group (S-T3) showed improved immune function, antigen presentation, and survival benefits correlated with genetic mutations.
Article Synopsis
- Paramyxoviruses, such as measles and Nipah, pose significant public health risks and have pandemic potential, with HPIV3 being a major cause of illness among vulnerable populations.
- * There are currently no approved vaccines or treatments for HPIV3, but neutralizing monoclonal antibodies (mAbs) could be a promising strategy despite challenges from viral resistance due to mutations.
- * The study presents cryo-electron tomography structures showing how mutated HPIV3 can evade neutralization by mAbs by altering the interaction between viral proteins, providing insights that could inform future mAb design.
Article Synopsis
- Human parainfluenza virus 3 (HPIV3) infection relies on the combined actions of the hemagglutinin-neuraminidase (HN) and fusion protein (F) to facilitate virus-cell membrane fusion for infection.
- Unlike laboratory-adapted strains, field strains of HPIV3 have different cleavage motifs for the F protein, which are cleaved by specific, unidentified proteases found in limited cell types.
- The study highlights that extracellular serine proteases, like TMPRSS2 and TMPRSS13, can activate the F protein for infectious virus release, suggesting that the activation process depends on the availability of these proteases in host cells.
Pulmonary arterial pressure (PAP) determines cattle's susceptibility to High Altitude Disease (HAD), also known as Brisket Disease, High Mountain Disease, and right-sided heart failure (RHF). This non-infectious disease causes pulmonary hypertension due to hypoxia. PAP measures the resistance of blood flow through the lungs.
View Article and Find Full Text PDFObjective: Minimally invasive surgery (MIS) is the standard approach for the staging and treatment of early-stage endometrial cancer (EC) and often includes use of a uterine manipulator. Uterine perforation is a known risk in this setting, and the impact of perforation and tumor spillage on cancer recurrence is largely unknown. The aim of this study was to assess the association between uterine perforation and/or tumor spillage at the time of MIS for low-grade, early-stage EC on disease recurrence.
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