Publications by authors named "K L Sheen"
Background: Recurrent early pregnancy loss [rEPL] is a traumatic experience, marked by feelings such as grief and depression, and often anxiety. Despite this, the psychological consequences of rEPL are often overlooked, particularly when considering future reproductive health or approaching subsequent pregnancies. The SARS-CoV-2 pandemic led to significant reconfiguration of maternity care and a negative impact on the perinatal experience, but the specific impact on women's experience of rEPL has yet to be explored.
View Article and Find Full Text PDFProblem And Background: During the COVID-19 pandemic, there was substantial reconfiguration of maternity care services, affecting both users and healthcare providers (HCPs), in the United Kingdom (UK) and globally.
Aim: To further our understanding of the impact of maternity service reconfigurations in the UK, from the perspective of maternity HCPs.
Methods: Scopus, MEDLINE, EMBASE, CINAHL, PsycINFO and the Cochrane COVID Study Register were searched for relevant studies reporting qualitative data from the UK, published in English between 01 June 2021 and 30 September 2023.
Article Synopsis
- Gastroesophageal Reflux Disease (GERD) leads to stomach contents flowing back into the esophagus, which may also affect ear health through the Eustachian tube.
- A study of over 669,000 South Korean patients found a strong link between GERD and the occurrence of tinnitus, suggesting that the ear issues could be related to reflux problems.
- However, treating GERD with proton pump inhibitors did not significantly lower the chances of developing tinnitus in these patients.*
Background: Women who suffer an early pregnancy loss require specific clinical care, aftercare, and ongoing support. In the UK, the clinical management of early pregnancy complications, including loss is provided mainly through specialist Early Pregnancy Assessment Units. The COVID-19 pandemic fundamentally changed the way in which maternity and gynaecological care was delivered, as health systems moved to rapidly reconfigure and re-organise services, aiming to reduce the risk and spread of SARS-CoV-2 infection.
View Article and Find Full Text PDFArticle Synopsis
- The LPS-induced inflammation model is valued for studying inflammation due to its cost-effectiveness and reliable results, but understanding gene regulation requires broader investigation beyond typical markers.
- Our research compared transcriptional profiles from LPS models to various human inflammatory diseases using whole-blood RNA-seq data, checking systems associated with inflammation.
- Findings revealed increased expression of innate immune genes and decreased adaptive immune gene expressions, highlighting oxidative stress as a key factor driving inflammatory responses across different contexts.