Publications by authors named "K L Sears"

Premise: Orthology inference is crucial for comparative genomics, and multiple algorithms have been developed to identify putative orthologs for downstream analyses. Despite the abundance of proposed solutions, including publicly available benchmarks, it is difficult to assess which tool is most suitable for plant species, which commonly have complex genomic histories.

Methods: We explored the performance of four orthology inference algorithms-OrthoFinder, SonicParanoid, Broccoli, and OrthNet-on eight Brassicaceae genomes in two groups: one group comprising only diploids and another set comprising the diploids, two mesopolyploids, and one recent hexaploid genome.

View Article and Find Full Text PDF

Purpose: To describe a case series of presumed Sympathetic Ophthalmia (SO) triggered by diode laser cyclophotocoagulation (CPC) for the treatment of neovascular glaucoma.

Methods: Patients developing bilateral granulomatous uveitis after CPC between 2014 and 2024. Cases with prior ocular trauma or penetrating ocular surgery were excluded.

View Article and Find Full Text PDF

This study examined the effects of blood flow restriction (BFR) on motor unit (MU) behaviour of the biceps brachii (BB) during a single non-exhausting submaximal muscle action. Twenty adults performed maximal voluntary contractions (MVCs) of the elbow flexors, followed by an isometric trapezoidal muscle action at 40% MVC during BFR and control (CON) visits. Surface electromyographic signals recorded from the BB during the 40% MVCs were decomposed.

View Article and Find Full Text PDF
Article Synopsis
  • - Medical exome sequencing involves multiple steps to identify and prioritize genetic variants before interpretation by professionals, ultimately aiming to provide meaningful reports to patients.
  • - A study examined over 13,000 curated variants from 289 patients, identifying 278 clinically significant SNPs and a large number of technical artifacts, with variant allele frequencies (VAFs) playing a crucial role in filtering.
  • - The research suggests that excluding SNPs with a VAF below 0.30 could streamline the curation process by about 20% without missing important medical variants.
View Article and Find Full Text PDF