Vitamin D status of ambulatory and nonambulatory mentally retarded children with and without carbamazepine treatment.

The subjects consisted of four groups: group 1 nonambulatory patients receiving carbamazepine; group 2 ambulatory patients receiving carbamazepine; group 3 nonambulatory patients receiving no drug, and group 4 ambulatory patients receiving no drugs. The serum 25-hydroxyvitamin D (25-OH-D) concentration was significantly lower in group 1 than in all other groups. There was no difference between the groups as regards the serum 1,25-dihydroxyvitamin D or 24,25-dihydroxyvitamin D concentration.

Comparison of ketanserin and pindolol in hypertension.

The antihypertensive effects of ketanserin (40 mg twice daily) and pindolol (5 mg twice daily) as monotherapy were compared in a crossover, double-blind trial in 17 patients with essential hypertension. Both ketanserin and pindolol decreased supine systolic and diastolic blood pressure significantly (P less than 0.01 for systolic and P less than 0.