Publications by authors named "K L Reagan"
Objectives: Serum galectin-3 (sGal-3) is a protein present in renal tubules and increases in experimental rodent models of acute kidney injury. The aim of this study was to compare sGal-3 concentrations in healthy cats and cats with ureteral obstruction (UO).
Methods: This was a retrospective study.
Case Summary: A 9-year-old male castrated domestic shorthair cat from northern California was evaluated for a 12-month history of dermal and subcutaneous dermatitis in the inguinal region. Histopathologic examination of a biopsy revealed severe, chronic, multifocal to coalescing pyogranulomatous dermatitis and panniculitis, accompanied by ulceration and central necrosis. Aerobic bacterial culture of lesions yielded mycobacterial growth.
View Article and Find Full Text PDFBackground: Before the discovery of effective antiviral drugs, feline infectious peritonitis (FIP) was a uniformly fatal disease of cats. Multiple antiviral treatments have been recognized, but optimization of treatment protocols is needed.
Objective: To evaluate the efficacy of PO molnupiravir (MPV; EIDD-2801) to treat effusive FIP.
Antibiotic treatment promotes the outgrowth of intestinal Candida albicans, but the mechanisms driving this fungal bloom remain incompletely understood. We identify oxygen as a resource required for post-antibiotic C. albicans expansion.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a machine learning model to diagnose portosystemic shunts (PSS) in dogs using normal demographic and clinicopathologic data, addressing the limitations of current diagnostic tests.
- The machine learning models developed included one to predict whether a dog has PSS and another to categorize the type of PSS, achieving high accuracy rates (94.3% sensitivity for PSS detection and 85.7% accuracy for subtype classification).
- These models can serve as effective screening tools to help veterinarians decide when to proceed with more advanced diagnostic techniques.