Publications by authors named "K L Mayer"
The diphthamide modification of eukaryotic translation elongation factor (eEF2) is important for accurate protein synthesis. While the enzymes for diphthamide synthesis are known, coordination of eEF2 synthesis with the diphthamide modification to maintain only modified eEF2 is unknown. Physical and genetic interactions extracted from BioGRID show a connection between diphthamide synthesis enzymes and chaperones in yeast.
View Article and Find Full Text PDFThis study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with -mutated ( ) AML. Targeted DNA sequencing of 263 genes was performed in 568 AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were (49.
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- Doxycycline postexposure prophylaxis (doxyPEP) effectively reduces the incidence of bacterial sexually transmitted infections (STIs) in those assigned male at birth, although practical data is limited.
- This study analyzed electronic health records of HIV PrEP users from Kaiser Permanente Northern California to assess the uptake of doxyPEP and its impact on STI rates before and after its initiation.
- Out of 11,551 HIV PrEP users, 19.5% received doxyPEP, with a notable percentage having an STI prior; findings suggest changes in STI positivity rates among those who started doxyPEP versus those who did not.
Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts. Here, we present reference genomes for Lilium sargentiae (lily, 35.
View Article and Find Full Text PDFPurpose: Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was associated with TNB adults' odds of screening for STI and HIV.
Methods: Longitudinal data came from the electronic medical records of TNB primary care patients receiving care at two community health centers located in Boston, Massachusetts, and New York City, New York, between January 2013 and December 2019.