Publications by authors named "K L Maurer"
Despite epidemiological data on anaemia being available on a global scale, its prevalence in the United Kingdom is not well described. To investigate anaemia prevalence and testing patterns for haemoglobin and other blood parameters. A population-based cohort study using data drawn from the Clinical Practice Research Datalink Aurum database in 2019.
View Article and Find Full Text PDFComparison of cell type and disease subset chromatin modifications in SLE.
Clin Epigenetics
November 2024
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse effects on different organs, and this study aims to understand how histone modifications impact disease persistence and cell-specific responses among patients.
- Analysis of samples from 20 SLE patients and 8 controls revealed significant variability in chromatin marks across T cells, B cells, and monocytes, with certain pathways like TNF and IL-2/STAT5 showing greater consistency across these cell types.
- The findings suggest that although each type of immune cell is affected differently, classical inflammatory pathways, particularly NFκB and IL-6 signaling, are common themes in the disease mechanisms associated with SLE.
Objectives: In this multi-center study, we proposed a structured reporting (SR) framework for non-small cell lung cancer (NSCLC) and developed a software-assisted tool to automatically translate image-based findings and annotations into TNM classifications. The aim of this study was to validate the software-assisted SR tool for NSCLC, assess its potential clinical impact in a proof-of-concept study, and evaluate current reporting standards in participating institutions.
Methods: A framework for SR and staging of NSCLC was developed in a multi-center collaboration.
Article Synopsis
- The study investigates the role of the cytokine TNFSF13 in epithelial and immune cell interactions, particularly relating to mucosal healing and inflammatory bowel disease (IBD).
- Researchers found that a specific variant of TNFSF13 led to reduced production of the cytokine, increased cell proliferation, and decreased cell death in colonic tissues.
- The research highlights TNFSF13's function as a key regulator of colonic epithelial growth and its interaction with B cells, which could have implications for understanding and treating IBD.
Article Synopsis
- Pediatric thermal injuries can lead to serious long-term physical and psychological issues; this study focused on comparing bacterial nanocellulose (BNC) and polyurethane foam (PU-foam) dressings in burn treatment.
- The prospective cohort study analyzed data from pediatric burn patients, examining factors like infection rates, hospital stay duration, and quality of life measures while accounting for differences in burn depth.
- Results indicated that BNC dressings contributed to shorter hospital stays and fewer anesthesia procedures compared to PU-foam, with similar scar outcomes and quality of life; further research is needed to validate these benefits.