Publications by authors named "K L Marsh"
Background: A decline in gait has been associated with an escalated risk of cognitive decline and changes in Alzheimer's disease (AD) biomarkers, thus offering prognostic insight. However, the utility of gait analysis in preclinical stages of AD is unclear, and prior studies have primarily used qualitative or gross measures of gait. Furthermore, gait analysis has predominantly been performed in cohorts of non-Hispanic Whites.
View Article and Find Full Text PDFBackground: Subjective cognitive decline (SCD) is thought to be a preclinical stage of Alzheimer's disease (AD), associated with faster disease progression and with imaging and cerebrospinal fluid biomarkers. However, it is unclear whether and how the degree of SCD correlates with plasma biomarkers. To address this, we investigated the association of plasma biomarkers of AD with established validated measures of SCD.
View Article and Find Full Text PDFBackground: Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80-100 or 'high ADI') is linked to structural inequities and increased risk of Alzheimer's disease neuropathology. Twenty percent of the US population resides within high ADI areas, predominantly in inner cities, tribal reservations and rural areas. The percentage of brain donors from high ADI areas within the Alzheimer's Disease Research Center (ADRC) brain bank system is unknown.
View Article and Find Full Text PDFBackground: Plasma biomarkers of Alzheimer's disease (AD) are less invasive and have lower costs than cerebrospinal fluid (CSF) biomarkers. Blood biomarkers are potential instruments for diagnosis, prognosis, and monitoring of disease progression. We assessed the diagnostic potential of several plasma biomarkers for the detection of early stages of AD.
View Article and Find Full Text PDFBackground: Assessment of anti-amyloid therapies for Alzheimer's disease (AD) requires understanding racial differences in brain amyloid. We compared amyloid burden in non-Hispanic Black/African American and White (NHB, NHW) adults in a cohort with over 40% NHB participants and explored factors associated with the inter-group differences.
Method: We included consecutive non-Hispanic participants who underwent brain amyloid PET-MRI exams in 2021-2023 at NYU Alzheimer's Disease Research Center.