[Coupling of calcium homeostasis and lipid peroxidation in mechanisms of bronchial hyperreactivity in patients with bronchial asthma].

A comparative study of calcium homeostasis, calcium regulating system and lipid peroxidation has been done with 16 bronchial asthma patients (BA) at bronchospasm of physical effort (BPhE) and with 15 asthma attack patients in remission period. The data obtained point to the close pathogenetic link between the changes of calcium homeostasis, hormonal calcium regulating system and LPO strengthening the appearance of hyperreactivity of bronchial tree and BA.

[The effect of a single dose of nifedipine, intal, sodium thiosulfate and Essentiale on the blood level of calcium, hydroperoxides, thiol compounds and prostaglandins in bronchial asthma patients].

A study was made of the impact of a single intake of nifedipine, intal, sodium thiosulfate and essentiale on respiratory function, the blood content of ionized calcium, total calcium, hydroperoxides, total and non-protein thiol groups, and prostaglandins in bronchial asthma patients. All the drugs exerted an antioxidant action, which is supported by the lowering of the content of hydroperoxides after their administration and by an increase of the content of thiol groups. A rise of the level of PGE and a considerable reduction of blood serum PGF2 alpha, most remarkable after essentiale administration were also noted.

[Calcium-regulating system in bronchial asthma].

Calcium homeostasis was determined from ionized calcium (Ca2+), total calcium (Cat) and bound calcium (Cab) levels, content of calcium-regulating hormones: calcitonin (CT) and parathyroid hormone (PTH). Lipid peroxidation (LPO) intensity was assessed from the blood plasma hydroperoxide level in 71 patients with bronchial asthma and chronic asthmatic bronchitis. The findings evidence that high blood serum levels of Ca2+ and Cab and a tendency to reduction of PTH content are characteristic of nonsevere and medium-severity atopic asthma.