Publications by authors named "K L Lucot"
Article Synopsis
- - TDP-43 pathology, linked to worse Alzheimer's disease (AD) outcomes, has mainly been studied in non-Hispanic White populations, prompting a broader ethnoracial evaluation.
- - The study analyzed TDP-43 pathology in 1,135 AD cases from various ethnoracial groups, finding no significant differences in pathology across these groups, despite imbalances in sample sizes.
- - Preliminary results suggest a lower prevalence of TDP-43 pathology in Hispanic/Latinos (34%) compared to non-Hispanic Whites (46%), indicating a need for more diverse research in this area.
Article Synopsis
- A study found age-related brain changes in two older polar bears, including amyloid plaques and tangles, similar to those seen in Alzheimer's disease in humans.
- The bears, aged 28 and 37, scored high on various assessment metrics related to neurodegeneration, indicating significant brain pathology.
- The research applies standardized guidelines for evaluating neurodegenerative changes, highlighting the potential for future comparative studies on aging in wildlife.
In 1984, the National Institute on Aging developed the Alzheimer's disease centers program. The main goal of these centers is to advance the understanding of Alzheimer's disease and related dementias (ADRD) through comprehensive patient evaluations and cutting-edge research in pathology, laboratory medicine, education, and scientific discovery. The neuropathology core of the Alzheimer's Disease Research Centers (ADRCs) collects postmortem brain tissue from consented donors ranging from cognitively normal individuals to those with late-stage dementia, whose samples and data can be shared around the world to further advance knowledge, diagnosis, and to eventually find cures for ADRD.
View Article and Find Full Text PDFParkinson's disease (PD) is associated with aberrant innate immune responses, including microglial activation and infiltration of peripheral myeloid cells into the central nervous system (CNS). Methods to investigate innate immune activation in PD are limited and have not yet elucidated key interactions between neuroinflammation and peripheral inflammation. Translocator protein 18 kDa (TSPO) PET is a widely evaluated imaging approach for studying activated microglia and peripheral myeloid lineage cells in vivo but has yet to be fully explored in PD.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease (AD) is a serious, progressive brain disorder with both hereditary and random forms, causing memory issues and affecting various cognitive functions.
- Diagnosis typically starts with noticing memory problems, but a definitive diagnosis can only be confirmed through brain autopsy to find specific markers like amyloid plaques.
- Recent research has significantly improved our knowledge of AD by uncovering genetic factors and mechanisms, leading to new possibilities for treatments and therapies.