Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification.

Huntington's disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading to altered gene expression. However, the mechanisms leading to disrupted RNA processing in HD remain unclear. Here we identify TDP-43 and the N6-methyladenosine (m6A) writer protein METTL3 to be upstream regulators of exon skipping in multiple HD systems.

Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons.

Down syndrome (DS), caused by trisomy 21, is characterized by intellectual disability and accelerated aging, with chronic oxidative stress contributing to neurological deficits. REST (Repressor Element-1 Silencing Transcription factor), a crucial regulator of neuronal gene expression implicated in DS neuropathology. This study investigates the neuroprotective potential of lithium, a mood stabilizer with known cognitive-enhancing effects, in restoring levels of REST.

Peritherapeutic intra-arterial flow changes predict long-term stent patency in patients with severe intracranial artery stenosis receiving PTAS.

Background And Purpose: The quantitative intra-arterial flow dynamics following percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial artery stenosis have never been investigated. We aimed to evaluate peritherapeutic intracranial artery flow dynamics following PTAS with quantitative magnetic resonance angiography (qMRA) to predict long-term stent patency.

Design: This is a prospective, single-center study.

Incidental finding of intravascular large B cell lymphoma in a multinodular goiter.

No abstract available.

Self-powered InSe/Ge photodetector from a visible to short-wave infrared region.

An InSe/Ge heterojunction is fabricated via molecular beam epitaxy. The p-n junction device features a broadened photosensitive spectrum ranging from a visible (VIS) to short-wave infrared (SWIR) region (400-1700 nm). Notably, self-powered high responsivity of 0.