Publications by authors named "K L Kage"
Article Synopsis
- Adoptive cellular therapy (ACT) using memory-like natural killer (NK) cells activated with specific cytokines shows promise in treating blood cancers, especially when combined with new fusion molecules.
- The multifunctional fusion molecule HCW9206 improves the expansion of NK cells that have been primed with another molecule (HCW9201), leading to a significant increase in their quantity and activity.
- The "Prime and Expand" strategy enhances NK cell metabolism and durability, making it a more efficient method for preparing clinical-grade NK cells for future cancer treatments.
Article Synopsis
- Elite and recreational climbers are at risk for disordered eating and injuries due to low energy availability (LEA), partly influenced by body image issues stemming from social media.
- A study of 324 adult U.S. climbers found that 78.7% prioritized a strong strength-to-weight ratio for climbing, and 59.3% believed they could climb better with different body proportions, linking these ideals to unhealthy weight loss and tracking behaviors.
- Higher social media engagement, especially with climbing influencers, and feelings of social physique anxiety were significant predictors of weight loss attempts, particularly among college-age females and frequent Instagram users seeking training and nutrition advice.
Background: The control of chronic inflammation has emerged as a target for improving the health of cancer survivors (CS).
Aim: To examine differences in fitness and dietary characteristics of CS when grouped by low vs. moderate to high serum C-reactive protein (CRP).
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH, 2-F, 3-F) of the pyridine hinge binding motif or replacement with pyrimidine afforded compounds with a clean CYP inhibition profile. Cocrystal structures of an early lead compound were obtained in PKA, ROCK1, and ROCK2.
View Article and Find Full Text PDFWe describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a structure surrogate to guide compound design. A subset of these molecules also showed robust activity in a cell-based myosin phosphatase assay and in a mechanical hyperalgesia in vivo pain model.
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