Publications by authors named "K L G Afeeza"
Article Synopsis
- Rubella, caused by a single-stranded RNA virus, can be effectively prevented through vaccination, and molecular docking is used to explore potential drug interactions with the virus's proteins.
- This study focused on a marine-derived compound, Rhizophorin, to assess its antiviral properties against the rubella capsid virus by using advanced docking techniques.
- Results indicated that Rhizophorin exhibits strong binding affinity to the rubella capsid protein, with critical hydrogen and hydrophobic interactions that highlight its potential as a therapeutic agent.
We have read the original article titled "P4HA2 contributes to head and neck squamous carcinoma progression and EMT through PI3K/AKT signaling pathway" by Yan-Ling Wu et al., which was published in the Medical Oncology journal, with great interest. This study provides valuable insights into the involvement of P4HA2 in the progression of head and neck squamous cell carcinoma (HNSCC), highlighting its potential as an oncogenic factor that promotes epithelial-mesenchymal transition (EMT), motility, invasion, and proliferation of cancer cells through the PI3K/AKT signaling pathway.
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- The monkeypox virus (MPXV) is a zoonotic virus, and the research explores the potential antiviral properties of fucoxanthin, a compound derived from seaweed, targeting MPXV through in silico analysis.
- A molecular docking analysis was performed using computational methods to assess the binding interactions between fucoxanthin and MPXV proteins, revealing a binding energy of -5.46 kcal/mol and specific amino acid interactions.
- The study concludes that fucoxanthin shows promise as an antiviral agent against MPXV, highlighting the effectiveness of bioactive seaweed compounds in combating viral infections.
Background Seagrass is rich in antioxidants, which can help neutralize harmful free radicals in the oral cavity. Free radicals can contribute to oxidative stress, inflammation, and various oral health issues. Incorporating seagrass extract into a hydrogel can enhance its antioxidant capacity, providing a protective effect for oral tissues.
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