Clinical-scale expansion of a mixed population of bone-marrow-derived stem and progenitor cells for potential use in bone-tissue regeneration.

Preclinical and clinical studies have demonstrated the ability of bone marrow derived stem and progenitor cells to regenerate many tissues, including bone. Methods to expand or enrich progenitors from bone marrow are common; however, these methods include many steps not amenable to clinical use. A closed automated cell production culture system was developed for clinical-scale ex vivo production of bone marrow-derived stem and progenitor cells for hematopoietic reconstitution.

Is infant mortality in Delaware truly increasing? Evidence for increasing illness severity and shift to fetal deaths and previable births.

The infant mortality rate, considered an important proxy for societal health, has been recently rising in Delaware. In fact, in 2001, Delaware's infant mortality rate (10.1/1,000 births) was the highest in the country.

MOMMA. Multi-centered On-going Mothers Monitoring Algorithm for perinatal behavioral health.

Depression during pregnancy and after delivery is a problem for the mother and poses a threat to the health of the fetus, the infant, and the family members. Low birth-weight babies have an increased risk for impaired cognitive function, cardiac disease, vascular disease, and diabetes. The incidence of depression during pregnancy and after delivery transforms an individual psychological problem into a problem of public health.