Publications by authors named "K L E Berry"
RAS is a common driver of cancer that was considered undruggable for decades. Recent advances have enabled the development of RAS inhibitors, but the efficacy of these inhibitors remains limited by resistance. Here, we developed a pan-RAS inhibitor, ADT-007, that binds nucleotide-free RAS to block GTP activation of effector interactions and MAPK/AKT signaling, resulting in mitotic arrest and apoptosis.
View Article and Find Full Text PDFBackground And Aims: Recently proposed "Rule-of-Five" criteria define compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension (CSPH) using liver stiffness (LS) and platelet count. We aimed to validate these criteria by determining whether they are associated with risk of adverse outcomes.
Approach And Results: Patients without prior hepatic decompensation or HCC who underwent LS and platelet measurements (n = 17,076) were categorized as follows: no cACLD (LS: 2.
Background: Digital mental health interventions are increasingly used to scale up access to mental health support, yet very few mental health apps are empirically supported, with high attrition rates. The therapeutic alliance between therapists and clients is a key factor in predicting psychological therapy retention and outcomes. Understanding how this concept translates to the digital context, the so-called digital therapeutic alliance (DTA), may help enhance retention and outcomes in digital mental health.
View Article and Find Full Text PDFArticle Synopsis
- Desert tortoise populations are declining due to diseases, predation, and habitat changes, raising questions about the role of minerals and heavy metals in their health.
- This study analyzed trace minerals and heavy metals in the tissues of sick and dying tortoises to explore their impact on health.
- Results showed that certain toxic metals were present in all tortoises, with juveniles showing higher levels of lead, tin, and zinc, indicating possible environmental health risks for these animals.
Objective: Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species.
Methods: A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training.