Publications by authors named "K L Duffin"
Objective: Limited knowledge exists regarding short-term changes/increases in concentrations of circulating proteins (referred here as deltas) and rapid development of kidney failure (rapid KF) in diabetes mellitus.
Research Design And Methods: Concentrations of 452 circulating proteins were measured by OLINK proteomics platform at baseline and after a median interval of 3-4 years in 106 individuals with type 1 and 77 with type 2 diabetes in two case-control studies. During 10-year follow-up, 31 and 26 individuals, respectively, developed rapid KF.
Many circulating proteins are associated with risk of ESKD, but their source and the biological pathways/disease processes they represent are unclear. Using OLINK proteomics platform, concentrations of 455 proteins were measured in plasma specimens obtained at baseline from 399 individuals with diabetes. Elevated concentrations of 46 circulating proteins were associated (P < 1 × 10-5) with development of ESKD (n = 143) during 7-15 years of follow-up.
View Article and Find Full Text PDFFactors Associated With Treatment Escalation for Psoriasis: An Analysis of Electronic Health Records Data.
J Psoriasis Psoriatic Arthritis
January 2024
Background: Electronic health records (EHRs) offer the possibility of using data entry templates to simultaneously document routine clinical care and capture disease-specific measures as discrete data elements that can be used for health services research (HSR). The objective of this study was to determine factors associated with meaningful treatment escalation (MTE) of psoriasis as a pilot study for future real-world HSR studies.
Methods: We conducted a retrospective, observational cohort study of psoriasis patients by using data collected during routine clinical care from an EHR using EpiCare® SmartForms.
Article Synopsis
- Advances in cancer treatment over the last twenty years have improved survival rates, especially for childhood cancers, but many therapies still risk future fertility.
- Fertility preservation programs are essential for both childhood and adult cancer patients because determining the actual risk of infertility post-treatment is complicated by the evolving nature of treatment plans.
- While cancer therapies have shifted towards more targeted approaches to minimize damage, this doesn't necessarily lower the risk of gonadotoxicity, making fertility preservation initiatives crucial in oncology care.