Publications by authors named "K L Colborn"
Article Synopsis
- Around 5-10% of pancreatic cancer patients don't express CA 19-9, and it's unclear how this affects their cancer severity and prognosis.
- A study analyzed data from 88,749 pancreatic cancer patients, finding that non-expressors had a higher chance of distant metastasis and a shorter median overall survival compared to those with normal CA 19-9 levels.
- The findings suggest that patients who are non-expressors of CA 19-9 might need different diagnostic approaches and more aggressive treatment strategies.
Background: We assessed the impact of breast cancer (BC) patients receiving their own patient-reported outcome (PRO) results on future PROs.
Methods: Newly diagnosed female BC patients completed validated measures of satisfaction with breasts (SB), and psychosocial (PsyW), physical (PhW), and sexual wellbeing (SW) longitudinally during treatment. Patients were randomized to receive their PRO scores (Intervention) or not (Control).
Objective: Improvement of surgical care is dependent upon evidence-based practices (EBPs), policies, procedures, and innovations. The objective of this study was to understand and synthesize the use of implementation science (IS) in surgical care.
Summary Background Data: This article summarizes the existing literature to identify the frequency and types of EBPs selected for surgical care, IS frameworks that guided the published research, and prominent facilitators and barriers.
Background: It is unclear how patient-reported outcomes (PROs) change longitudinally after breast cancer surgery. We sought to compare trends in PROs among patients who underwent lumpectomy versus mastectomy over the first year after surgery.
Patients And Methods: Newly diagnosed stage 0-III female patients with breast cancer who underwent lumpectomy or mastectomy at an academic breast center between June 2019 and March 2023 were invited to participate in a longitudinal PRO study.
Article Synopsis
- The study investigates the impact of preoperative chemo(radio)therapy on patients with localized pancreatic adenocarcinoma, focusing on the rare occurrence of pathological complete response (pCR), where no cancer cells are found post-surgery.
- Conducted in 19 centers across 8 countries with 1758 participants, the research shows that only 4.8% of patients achieved pCR, which is linked to better overall survival rates compared to those who did not achieve pCR.
- Factors influencing the likelihood of pCR included the use of multiagent chemotherapy regimens other than the (m)FOLFIRINOX treatment, highlighting the need for tailored therapeutic approaches.