Publications by authors named "K L Clay"

Compliance with hand hygiene is an effective way of reducing the incidence of healthcare acquired infections (HCAI). At one London National Health Service (NHS) Trust, improving hand hygiene compliance (HHC) was a patient safety priority in response to non-compliance and ongoing occurrences of HCAI. The objective of this study was to co-design a behavioural science informed intervention to improve HHC.

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  • - This study analyzed the bacterial communities in the blood samples of 79 living and 7 road-killed lowland tapirs to understand their blood microbiota, highlighting the importance of studying blood alongside gut microbiomes.
  • - Researchers identified significant differences in bacterial diversity based on animal condition (living vs. road-killed), age, and location, revealing the presence of various vector-borne bacterial pathogens in the tapirs' blood.
  • - Using next-generation sequencing, the study provided new insights into the blood microbiome of lowland tapirs, suggesting potential microbial movement from other body areas to the bloodstream and the diagnostic utility of this approach for pathogen screening.
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  • Research suggests the best lifespan-extending compounds target multiple receptors related to biogenic amines.
  • Using graph neural networks, researchers predicted compounds that could potentially extend lifespan and tested them.
  • Over 70% of the tested compounds successfully extended lifespan, marking them as highly effective compared to existing data in the DrugAge database.
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Sequence-specific transcription factors often function as components of large regulatory complexes. LIM-domain binding protein (LDB) and single-stranded DNA-binding protein (SSDP) function as core scaffolds of transcriptional complexes in animals and plants. Little is known about potential partners and functions for LDB/SSDP complexes in the context of tissue regeneration.

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