Publications by authors named "K L Briggs"
Article Synopsis
- TNG908 is a clinical-stage inhibitor targeting PRMT5, utilizing a unique binding mechanism that exploits the loss of the MTAP gene commonly found in various cancers.
- It specifically inhibits PRMT5 in cancer cells lacking MTAP, which occurs in 10-15% of human cancers and could lead to more effective treatments compared to earlier drugs.
- Ongoing Phase I/II trials are investigating the effectiveness of TNG908 in patients with MTAP-null tumors, including glioblastoma, suggesting a promising future for this therapy in multiple cancer types, particularly those affecting the brain.
Background: High altitude may induce physiological changes that can predispose patients to venous thromboembolism (VTE), a relatively uncommon, but potentially fatal complication following total knee arthroplasty (TKA). The purpose of this study was to determine if high altitude is an independent risk factor for postoperative VTE following TKA.
Methods: A large claims database was queried for patients who underwent TKA at high-altitude (≥ 1,219-meters) and low-altitude (≤ 30-meters) using Current Procedural Terminology codes, International Classification of Disease codes, and zip codes.
Article Synopsis
- The study evaluated the success of oncological microdissection testicular sperm extraction (onco-microTESE) in patients with testicular cancer, specifically those with azoospermia and severe sperm deficiencies.
- Out of 31 azoospermic patients, the initial procedure was successful for 61%, with an overall fertility preservation success rate of 71%, including additional successes from contralateral microTESE.
- The procedures were performed relatively quickly, averaging about 7 days from patient referral to surgery, making this a viable option for preserving fertility without delaying cancer treatment.
Background: Total knee arthroplasty (TKA) is the procedure of choice for osteoarthritis of the knee (OAK) when conservative treatment fails; however, high rates of dissatisfaction and poor implant longevity dissuade younger patients from TKA. There is a paucity of evidence that report outcomes and clinical effectiveness of arthroscopic knee procedures in patients with end-stage (grade 3-4) OAK. The purpose of this systematic review was to evaluate the efficacy of arthroscopic treatment for patients with moderate-to-severe (grade 3-4) OAK.
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- Dendritic cells (DCs) play a crucial role in the immune system by capturing and presenting antigens, particularly in response to infections like avian influenza virus (AIV) in chickens.
- The study investigates the effects of high pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) on chicken bone marrow-derived DCs, highlighting significant immune responses, morphological changes, and viral replication.
- Key findings include strong proinflammatory responses and distinctive changes in cell shape leading to cell death, indicating a dysregulated immune response more prevalent in HPAI infections compared to LPAI.