Publications by authors named "K L Bressler"
Introduction: The shortage of physicians in rural Canada is a continuing challenge. Canadian medical schools have adapted strategies to increase the supply of rural physicians. This study appraises the effectiveness of the living library (also called Human Library©) in medical education, as an avenue for medical and pre-medical students to engage in dialogue with rural health professionals.
View Article and Find Full Text PDFBackground: Neuroendocrine prostate cancer (NEPC) encompasses pure NEPC and tumors with mixed adenocarcinoma and neuroendocrine histology. While NEPC is thought to confer a poor prognosis, outcome data are sparse, making risk stratification and treatment decisions difficult for clinicians.
Methods: This retrospective study identified patients with morphological and/or immunohistochemical NEPC features on pathological review of high-grade prostate cancer cases.
Article Synopsis
- * Depleting eIF5B removes the regulatory repression of ATF4 mRNA translation via uORF, leading to increased transcription of GADD34 and potentially altering the cell's transcriptome profile.
- * Genome-wide analysis of eIF5B-depleted cells revealed upregulated pathways related to ER stress and mucin-type O-glycan biosynthesis, while pathways linked to cancer misregulation and T cell signaling were downregulated, also activating the JNK MAPK pathway.