Publications by authors named "K L Bland"
Article Synopsis
- CycloAnt is an opioid peptide effective in pain relief (antinociception) with fewer side effects when tested systemically in mice.
- It shows stability against degradation in mouse serum and is resistant to metabolism in the liver, indicating a long-lasting effect in the body.
- CycloAnt successfully crosses the blood-brain barrier, aided by its flexible structure that changes shape depending on its environment, enhancing its ability to penetrate the brain.
Background: As the prevalence of chemotherapy-related cognitive impairment rises, investigation into treatment options is critical. The objectives of this study were to test the effects of an aerobic exercise intervention initiated during chemotherapy compared to usual care (wait list control condition) on (1) objectively measured cognitive function and self-reported cognitive function, as well as on (2) the impact of cognitive impairment on quality of life (QOL) postintervention (commensurate with chemotherapy completion).
Methods: The Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial was a two-arm, two-center randomized controlled trial conducted in Ottawa and Vancouver (Canada).
Unlabelled: People with advanced cancer and cachexia experience significant body weight loss, adversely impacting physical function and quality of life (QOL). Effective, evidence-based treatments for cancer cachexia are lacking, leaving patients with unmet needs. Exercise holds promise to improve patient QOL.
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