Publications by authors named "K Kuschnerus"
Article Synopsis
- The study aimed to evaluate how well different types of vascular patches (bovine, equine, and human autologous pericardium) are accepted by the body when used for repairing congenital heart defects.
- Various histological techniques were employed to analyze tissue composition and assess biocompatibility, scoring factors like inflammation and degradation.
- Results showed that human autologous patches had better biocompatibility compared to tissue-engineered types, with bovine patches demonstrating significant calcifications and equine patches showing more foreign body reactions.
Bridge to recovery using an Impella 2.5 device in a 3-year-old child.
Eur J Cardiothorac Surg
April 2023
Mechanical support options for children and small adolescents with acute left ventricular failure are often limited to extracorporeal life support (ECLS) and subsequent left ventricular assist device implantation. We report a case of a 3-year-old child weighing 12 kg with acute humoral rejection after cardiac transplantation not adequately responding to medical therapy who presented in persistent low cardiac output syndrome. We successfully stabilized the patient by implanting a Impella 2.
View Article and Find Full Text PDFMid-term performance of decellularized equine pericardium in congenital heart surgery.
Interact Cardiovasc Thorac Surg
November 2022
Objective: The aim was to report mid-term performance of decellularized equine pericardium used for repair of various congenital heart defects in the pediatric population.
Methods: A retrospective review of all patients undergoing patch implantation between 2016 - 2020 was performed. Patch quality, surgical handling, hemostasis and early patch-related complications were studied on all patients.
Inflammasomes are crucial gatekeepers of the immune response, but their maladaptive activation associates with inflammatory pathologies. Besides canonical activation, monocytes can trigger non-transcriptional or rapid inflammasome activation that has not been well defined in the context of acute myocardial infarction (AMI). Rapid transcription-independent inflammasome activation induced by simultaneous TLR priming and triggering stimulus was measured by caspase-1 (CASP1) activity and interleukin release.
View Article and Find Full Text PDFObjectives: The aim of this study was to report our initial experience when using Matrix Patch™ a cell-free equine-derived pericardium for the augmentation of branch pulmonary arteries (PAs) in children.
Methods: Between September 2016 and September 2019, Matrix Patch was used for the augmentation of branch PAs in 96 patients and implanted in 147 separate locations. The median age at implantation was 3.