Publications by authors named "K Kuroiwa"
Animals must avoid adhesion to objects in the environment to maintain their mobility and independence. The marine invertebrate chordate ascidians are characterized by an acellular matrix tunic enveloping their entire body for protection and swimming. The tunic of ascidian larvae consists of a surface cuticle layer and inner matrix layer.
View Article and Find Full Text PDFBackground: In Japan, since 2014, new treatments such as androgen receptor signaling inhibitors and cabazitaxel have become applicable for metastatic castration-resistant prostate cancer (mCRPC), leading to dramatic changes in treatment options.
Objective: This study aims to evaluate the impact of recent advancements in treatment options on the overall survival (OS) of patients diagnosed with de novo metastatic castration-sensitive prostate cancer (mCSPC) in Japan.
Methods: A retrospective analysis was conducted on 2450 Japanese men diagnosed with de novo mCSPC between 2008 and 2018.
Article Synopsis
- * Imaging tests revealed multiple brain and lung nodules, and blood tests indicated symptoms consistent with hemophagocytic syndrome.
- * A bone marrow examination confirmed the presence of Toxoplasma gondii, leading to treatment; however, the patient ultimately developed multiple organ failure and died shortly after admission.
Article Synopsis
- Most follicular lymphomas (FLs) are typically slow-progressing with good outcomes, but some patients face disease worsening within 24 months (POD24), leading to poorer results.
- This study aimed to identify predictive risk factors for POD24 and analyze the microenvironment characteristics in FL patients experiencing POD24.
- The research found that higher Ki-67 expression significantly correlates with POD24 events, and those patients also showed a decrease in certain immune cells, suggesting implications for targeted treatment approaches.
Supramolecular Hybrids of Proteins from Habu Snake Venom with Discrete [Pt(CN)] Complex.
ACS Appl Mater Interfaces
November 2024
Article Synopsis
- - The Habu snake's venom contains diverse proteins, particularly phospholipase A (PLA) enzymes, which are valuable for studying molecular evolution but lack understanding in their physical properties and self-assembly.
- - This research explores the interaction of purified PLA enzymes with anionic metal complexes, revealing that they can form microstructures that grow into fibrous structures in a buffered saline solution.
- - The results suggest new possibilities for developing flexible and functional hybrid systems using snake venom enzymes, highlighting potential applications in nanotechnology and bioengineering.