Publications by authors named "K Kurata"
Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), in intestinal epithelial cells significantly contribute to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Given our previous findings that TNF-α is upregulated in intestinal epithelial Caco-2 cells induced by skatole, a tryptophan-derived gut microbiota metabolite, the present study aimed to explore the relationship between skatole and IL-6, alongside TNF-α. Skatole elevated the promoter activity of IL-6 as well as TNF-α, and increased IL-6 mRNA expression and protein secretion.
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- - A new vaccine called MAFB-7256a (DS-5670d) was developed in Japan and approved in Spring 2024 to prevent COVID-19, but there's currently no clinical efficacy data available for it.
- - Researchers utilized a method called QASAS to assess the immune response of three healthy volunteers before and after they received the MAFB-7256a vaccination.
- - The study found that B-cell receptor responses increased quickly one week after vaccination and then decreased, with antibodies specifically targeting the receptor-binding domain (RBD) of the virus, indicating the vaccine's focused immunogenicity.
Article Synopsis
- The study assessed the effects of prophylactic neck dissection and additional therapy on patients undergoing transoral surgery for hypopharyngeal cancer from 2015 to 2021.
- Out of 221 patients, a high 3-year local recurrence-free survival rate of 89.1% was observed, but positive margins led to higher rates of regional recurrence and distant metastasis, though local recurrence did not affect overall survival.
- The conclusion suggests that monitoring for recurrences is important and that prophylactic neck dissection might not be essential for all patients with positive margins.
Background: Advancements in technology have overcome geographical barriers, making telemedicine, which offers remote emergency services, healthcare, and medication guidance, increasingly popular. COVID-19 restrictions amplified its global importance by bridging distances.
Objective: This study aimed to analyze Chinese and global literature data, present new global telemedicine research trends, and clarify the development potential, collaborations, and deficiencies in China's telemedicine research.