Publications by authors named "K Kuramitsu"
Less than half of all patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) respond to chemotherapy, and the prognosis of PDAC is poor, which may be mediated by the gut microbiota. We investigated the clinical improvement effects of 1-kestose, a fructooligosaccharide, on PDAC chemotherapy in this single-center, randomized, controlled pilot trial conducted at Fujita Health University Hospital, which enrolled patients with PDAC. The trial included 1-kestose administration and non-administration groups.
View Article and Find Full Text PDFChronic inflammation in adipose tissue is thought to contribute to insulin resistance, which involves the gut microbiota. Our previous studies have demonstrated that ingestion of 1-kestose can alter the gut microbiota composition, increase cecal butyrate levels, and improve insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Additionally, we found that 1-kestose supplementation ameliorated insulin resistance in obese rat models fed a high-fat diet (HFD), although the effects of 1-kestose on the abundance of inflammation-related gene in adipose tissue and gut microbiota composition in these rats were not explored.
View Article and Find Full Text PDFArticle Synopsis
- The study assesses the effectiveness of EOB-MRI in predicting post-hepatectomy liver failure (PHLF) specifically in patients with hepatocellular carcinoma (HCC) and major portal vein tumor thrombus (PVTT).
- It included 21 patients with Vp3 PVTT and 30 with Vp4 PVTT, measuring functional future remnant liver volume (fFRLV) through signal intensity on MRI.
- Results showed that the fFRLV in the Vp3 group successfully predicted PHLF with significant accuracy, while the Vp4 group did not yield predictive results above a certain threshold.
Background: The Global Leadership Initiative on Malnutrition (GLIM), comprising several of the major global clinical nutrition societies, suggested the world's first criteria for diagnosis of the severity of malnutrition. However, the impact of the resulting diagnosis on patient outcomes for those with hepatocellular carcinoma (HCC) following liver resection (LR) has not been investigated.
Methods: A retrospective analysis of 293 patients with HCC who underwent LR between January 2011 and December 2018 was performed.
Article Synopsis
- Postoperative cholangitis is a common issue following pancreaticoduodenectomy, negatively affecting patients' quality of life, and this study sought to identify factors that contribute to its recurrence.
- The study analyzed medical records from patients who had the surgery between 2015 and 2019, defining recurrence as having at least two episodes of cholangitis within a year post-surgery.
- Key risk factors for recurrence identified were the presence of internal stents, a firm pancreas, constipation, and elevated bilirubin levels, with long-term stent placement further increasing recurrence rates.