Publications by authors named "K Kurachi"
Goals: To clarify the characteristics of desmoid tumors in Japanese patients with familial adenomatous polyposis after colectomy.
Background: Few comprehensive reports have been published on desmoid tumors in Asian patients with familial adenomatous polyposis.
Study: This retrospective study included the data of 81 patients with familial adenomatous polyposis who underwent surgery between 1978 and 2021.
Far ultraviolet-C irradiation at 222 nm has potent bactericidal effects against severe infections such as peritonitis, with minimal cytotoxicity. Bacterial peritonitis due to bowel perforation is a serious condition with high mortality despite current treatments. This study investigated the safety and efficacy of intraperitoneal far ultraviolet-C irradiation at 222 nm.
View Article and Find Full Text PDFBackground: Crohn's disease causes acute and chronic inflammation that often make the preoperative evaluation of surgical risks difficult. Myosteatosis is used for the evaluation of muscle quality to assess sarcopenia. However, data on the relationship between myosteatosis and surgical outcomes in patients with Crohn's disease are lacking.
View Article and Find Full Text PDFArticle Synopsis
- Malignant mesothelioma (MM), linked to asbestos exposure, is increasingly prevalent and resistant to treatment, making the study of its underlying mechanisms crucial.
- Researchers found that the platelet-derived growth factor receptor (PDGFR) ligand, PDGF-BB, boosts CTGF protein levels in MM cells without changing CTGF mRNA levels, indicating a unique regulation mechanism.
- PDGFR activation triggers the AKT pathway, which is vital for increasing CTGF protein expression, suggesting that targeting these pathways could be key in addressing MM malignancy.
Article Synopsis
- - The study examined how changes in the prognostic nutritional index (PNI) before and after surgery impact outcomes in patients with colorectal cancer, focusing on those with stage II/III disease.
- - Results showed that patients with a decrease in PNI post-surgery had significantly higher rates of recurrence and mortality, indicating worse overall and recurrence-free survival compared to those whose PNI did not decrease.
- - The findings suggest that monitoring perioperative PNI changes could serve as an effective way to predict a patient's prognosis and risk of cancer recurrence following surgery.