Publications by authors named "K Kundu"
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients with myeloid malignancies display global dysfunction with impaired killing capacity, altered metabolism, and an exhausted phenotype at the single-cell transcriptomic and proteomic levels. In this study, we identified that this dysfunction was mediated through a cross-talk between NK cells and myeloid blasts necessitating cell-cell contact.
View Article and Find Full Text PDFPhotoswitchable (pre)catalysts, N,N'-bis-azobenzene-based (NHC)gold(I) and N,N'-bis-azobenzene-derived (NHC)copper(I) complexes are reported. Trans to cis isomerization of the attached photoswitchable moieties in the Au(I) complex enables four-fold decrement in the rate of oxazoline formation reaction. Whereas the progress of the copper(I) catalyzed, azide-alkyne cycloaddition reaction gets reduced by at least threefold.
View Article and Find Full Text PDFObjective: Medical nutrition therapy is an essential component of management of type 1 diabetes (T1D). This study evaluated adherence of children with T1D to ISPAD 2018dietary recommendations.
Methods: Dietary assessmentconducted for 75 children with T1D of duration > 1-year.
Article Synopsis
- Contrast-enhanced CT scans are the standard for assessing lung lesions, but distinguishing between benign and malignant types can be challenging due to overlapping features, necessitating invasive procedures for diagnosis.
- The study aimed to evaluate the effectiveness of CT perfusion technology in non-invasively differentiating between malignant and benign lung lesions by measuring parameters like blood flow and blood volume.
- Results demonstrated significant differences in blood volume between benign (median 5.5 mL/100 g) and malignant lesions (median 11.35 mL/100 g), indicating that CT perfusion could be a valuable tool for non-invasive differentiation of lung lesions.