Muscle MRI Pattern in Dysferlinopathy and its Correlation with Dysferlin Gait.

Background And Objectives: Magnetic resonance imaging (MRI) in dysferlinopathy has consistently demonstrated a particular pattern of affliction. We aimed to study muscle MRI characteristics of lower limbs in limb girdle muscular dystrophy (LGMD)-R2 phenotypes and correlate them with the gait pattern.

Methods: Forty genetically and/or biopsy-proven cases of dysferlinopathy underwent muscle MRI of the lower limbs.

Phenotype, outcome, interleukins, and miRNA levels assessment of new-onset refractory status epilepticus: A prospective cohort study.

Objectives: New-onset refractory status epilepticus (NORSE), a subtype of status epilepticus, poses a critical neurological emergency marked by considerable morbidity and mortality. This study aimed to characterize NORSE phenotypically and assess its outcomes, interleukin levels, and miRNA levels.

Methods: Over a 3-year period, patients presenting with NORSE were enrolled.

Involvement of the Superior Cerebellar Peduncles in GAA- Ataxia.

Objectives: GAA- ataxia (SCA27B) is a recently reported late-onset ataxia caused by a GAA repeat expansion in intron 1 of the gene. After the clinical observation of superior cerebellar peduncle (SCP) involvement in some affected patients, we sought to verify the prevalence of this finding in our cohort and 4 additional independent cohorts of patients with SCA27B.

Methods: We performed a retrospective review of the brain MRI scans of a total of 87 patients (median age at MRI 69 years; range 28-88 years) from different independent cohorts to assess the presence of SCP involvement, defined as abnormally high T2 signal along the SCP tract.

Prediction of meningioma subtypes using qualitative assessment of fractional anisotropy maps.

Aim: In this study, we explore the role of FA maps in predicting the histopathological subtypes of meningioma using a qualitative ordinal scale and quantitative histogram features.

Material & Methods: Retrospective analysis of grey-scale FA maps of 96 cases of meningioma was done by two observers blinded to the histopathological diagnosis. An ordinal scale of 1-4 was used to grade the degree of FA in each lesion.