Drosophila selected for extended longevity are more sensitive to heat shock.

It has been demonstrated in several animal models that a brief non-lethal application of high temperature is capable of inducing an increased longevity. It is also known that an even briefer exposure to a non-lethal elevated temperature enables some organisms to subsequently survive what would normally be a lethal exposure to high temperature. Our long-lived La strain is significantly resistant to oxidative stress due to an enhanced expression of certain antioxidant defense genes and enzyme activities.