Specific immunotherapy stimulates the binding of histamine H2 receptor antagonist by lymphocytes.

The binding of antagonists of histamine receptors H1 (promethazine) and H2 (ranitidine) by peripheral blood lymphocytes from pollinotics was determined before and after the course of immunotherapy. We found that lymphocytes from atopic subjects showed significant decrease in the binding of H2 receptor antagonist as compared to control subjects. Specific immunotherapy induced statistically significant increase in H2 receptor antagonist binding, which correlated with the improvement of clinical symptoms.

Impaired histamine binding by gastric juice of patients with duodenal ulcer.

Histamine binding by gastric juice from 32 patients with duodenal ulcer and 22 control subjects was tested in vitro. The patients had substantially decreased histamine binding both in basal output as well as in pentagastrin stimulated output. The authors suggest that this phenomenon is involved in etiopathogenesis of chronic ulcer disease.

Binding of histamine by gastric juice.

Ability of in vitro histamine binding by gastric juice was tested in aspirates from 10 normal subjects, collected during basal acid output (BAO) as well as after pentagastrin stimulation (maximal acid output - MAO). Histamine binding by 1 ml of gastric juice averaged 218.7 micrograms and after stimulation with pentagastrin was about 31% higher.