Aplastic anemia secondary to tyrosine kinase inhibitor therapy in a patient with chronic myeloid leukemia.

Introduction: Nilotinib, as the second generation of tyrosine kinase inhibitor, has significant efficacy in patients with chronic myeloid leukemia resistant or intolerant to Imatinib. Aplastic anemia induced by tyrosine kinase inhibitors is an uncommon complication.

Case Report: A 34-year-old female case with CML in the chronic phase was treated with Imatinib in first-line therapy.

Protective effect of Urtica dioica in induced neurobehavioral changes, nephrotoxicity and hepatotoxicity after chronic exposure to potassium bromate in rats.

Background And Purpose: Chronic exposure to potassium bromate (KBrO), a toxic halogen in the environment, has become a global problem of public health. The current study aims to elucidate for the first time the effect of Urtica dioica (UD) on behavioural changes, oxidative stress, and histopathological changes induced by KBrO in the cerebellum, kidney, liver and other organs of adult rats.

Study Design And Methods: The rats were divided into four groups: group 1 served as a control received physiological serum, Group 2 received KBrO (2 g/L of drinking water), group 3 received KBrO and Urtica dioica (100 mg/kg), and group 4 received KBrO and Urtica dioica (400 mg/kg).