Publications by authors named "K Kremer"
Objective: The most common medically resistant epilepsy (MRE) involves the temporal lobe (TLE), and children designated as temporal plus epilepsy (TLE+) have a five-times increased risk of postoperative surgical failure. This retrospective, blinded, cross-sectional study aimed to correlate visual and computational analyses of magnetoencephalography (MEG) virtual sensor waveforms with surgical outcome and epilepsy classification (TLE and TLE+).
Methods: Patients with MRE who underwent MEG and iEEG monitoring and had at least 1 year of postsurgical follow-up were included in this retrospective analysis.
Objective: Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants. We sought to understand the safety and potential efficacy of preventative sirolimus in infants with TSC.
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- Whole genome sequencing (WGS) of Mycobacterium tuberculosis complex (MTBC) is greatly affected by the effectiveness of DNA extraction protocols, particularly the lysis step.
- In a study comparing four different DNA extraction methods, a bead beating protocol (protocol B) significantly increased DNA yield by 60-fold and improved sequencing success rates.
- Incorporating mechanical lysis not only enhances extraction from primary cultures but also enables earlier WGS from enriched cultures, ultimately reducing turnaround time while maintaining high-quality DNA needed for analysis.
Objective: To evaluate 2 years of clinical experience with markerless breath-hold liver stereotactic radiotherapy (SBRT) using noninvasive nasal high-flow therapy (NHFT) for breath-hold prolonging and surface guidance (SGRT) for monitoring.
Methods: Heated and humidified air was administered via a nasal cannula (40 L/min, 80% oxygen, 34 °C). Patients performed voluntary inspiration breath-holds with visual feedback.
Using molecular dynamics simulations, we show that the methodology of making thin stable nanoporous monodisperse films by biaxial mechanical expansion and subsequent cooling into the glassy state, also works for polydisperse films. To test this, a bidisperse polymer system of an equal number of very long (≈72 entanglements) and short (≤4 entanglements) chains with a polydispersity index of 1.80 is considered.
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