Effect of tranexamic acid on blood loss reduction after cardiopulmonary bypass.

Objective: We evaluated the effect of tranexamic acid on blood loss in patients undergoing elective cardiopulmonary bypass for coronary artery bypass surgery.

Methods: We randomly assigned 7 of 14 patients to a group receiving 50 mg/kg tranexamic acid before skin incision and after the start of cardiopulmonary bypass and the other 7 as controls.

Results: Intraoperative and postoperative blood loss was significantly (p = 0.