Chemical extension and glycodendrimer formation of the matriglycan decasaccharide, -(3Xylα1-3GlcAβ1)- and its affinity for laminin.

Muscle tissue is stabilized by the strong interaction between laminin and matriglycan. Matriglycan is a polysaccharide composed of the repeating disaccharide, -3Xylα1-3GlcAβ1-, and is a pivotal part of the core M3 O-mannosyl glycan. Patients with muscular dystrophy cannot synthesize matriglycan or the core M3 O-mannosyl glycan due to a defect in or the lack of glycosyltransferases owing to glycan synthesis.

Loss of Coherence and Change in Emission Physics for Radio Emission from Very Inclined Cosmic-Ray Air Showers.

Next-generation radio experiments such as the radio detector of the upgraded Pierre Auger Observatory and the planned GRAND and BEACON arrays target the detection of ultra-high-energy particle air showers arriving at low elevation angles. These inclined cosmic-ray air showers develop higher in the atmosphere than vertical ones, enhancing magnetic deflections of electrons and positrons inside the cascade. We evidence two novel features in their radio emission: a new polarization pattern, consistent with a geosynchrotron emission model and a coherence loss of the radio emission, both for showers with zenith angle θ≳65° and strong enough magnetic field amplitude (typical strength of B∼50  μT).

Search for the Pair Production of Dark Particles X with K_{L}^{0}→XX, X→γγ.

We present the first search for the pair production of dark particles X via K_{L}^{0}→XX with X decaying into two photons using the data collected by the KOTO experiment. No signal was observed in the mass range of 40-110  MeV/c^{2} and 210-240  MeV/c^{2}. This sets upper limits on the branching fractions as B(K_{L}^{0}→XX)<(1-4)×10^{-7} and B(K_{L}^{0}→XX)<(1-2)×10^{-6} at the 90% confidence level for the two mass regions, respectively.

Search for the Majorana Nature of Neutrinos in the Inverted Mass Ordering Region with KamLAND-Zen.

The KamLAND-Zen experiment has provided stringent constraints on the neutrinoless double-beta (0νββ) decay half-life in ^{136}Xe using a xenon-loaded liquid scintillator. We report an improved search using an upgraded detector with almost double the amount of xenon and an ultralow radioactivity container, corresponding to an exposure of 970 kg yr of ^{136}Xe. These new data provide valuable insight into backgrounds, especially from cosmic muon spallation of xenon, and have required the use of novel background rejection techniques.

Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin.

Matriglycan, a polysaccharide that is a pivotal part of the core M3 -mannosyl glycan composed of the repeating disaccharide -3Xylα1-3GlcAβ1-, interacts with laminin to stabilize muscle tissue. We herein report the synthesis of matriglycan-repeating hexasaccharides equipped with an alkyne linker to form glycoconjugates. The key step in the formation of an α-linked xylosyl glycoside was resolved by solvent-specific separation from an anomeric mixture.