Publications by authors named "K Koszoru"
This study aims to explore the measurement agreement between direct and indirect health utility measures in four chronic dermatological conditions (atopic dermatitis, hidradenitis suppurativa, pemphigus, psoriasis). Outpatients survey data collected between 2015 and 2021 were analysed. Health-related quality of life (HRQoL) outcome measures included time trade-off (TTO), EQ-5D-5L and Dermatology Life Quality Index (DLQI).
View Article and Find Full Text PDFBullous pemphigoid (BP) is an autoantibody-mediated blistering skin disease characterized by local inflammation and dermal-epidermal separation, with no approved targeted therapy. The Syk tyrosine kinase is critical for various functions of the immune response. Second-generation Syk inhibitors such as entospletinib are currently being tested for hematological malignancies.
View Article and Find Full Text PDF[Dermatitis herpetiformis and other forms of wheat sensitivity].
Dermatologie (Heidelb)
December 2022
Background: Wheat sensitivity is a collective term for several, especially gastrointestinal, diseases that occur as part of a hypersensitivity reaction after wheat consumption. The symptoms, which are mostly similar to those of irritable bowel syndrome, are often accompanied by skin lesions. In addition to celiac disease and dermatitis herpetiformis, the cutaneous manifestation of celiac disease, wheat sensitivity also includes nonceliac gluten sensitivity (NCGS), allergic nickel contact mucositis, wheat allergy, amylase-trypsin inhibitor intolerance, and fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) intolerance.
View Article and Find Full Text PDFArticle Synopsis
- Dermatitis herpetiformis (DH) is a rare skin condition triggered by gluten, characterized by the presence of specific IgA autoantibodies against proteins like endomysium and transglutaminase.
- An international study analyzed serum samples from 242 DH patients at diagnosis, using various methods including indirect immunofluorescence on monkey oesophagus and ELISA tests for specific autoantibodies.
- The findings showed that IgA antibodies detected via indirect immunofluorescence had the highest reactivity and diagnostic accuracy, indicating a strong link between these autoantibodies and DH, which can be further improved with additional testing.
Background: Cost-of-illness studies are widely used for healthcare decision-making in chronic conditions. Our aim was to assess the cost-of-illness of adult atopic dermatitis (AD) from the societal perspective in Hungary.
Methods: We conducted a multicentre, cross-sectional questionnaire survey between February 2018 and January 2021.